Bioorthogonal catalysis in complex media: Consequences of using polymeric scaffold materials on catalyst stability and activity

Bioorthogonal catalysis using transition-metal-based complexes (TMCs) is a promising approach for converting substrates to desired products in complex cellular media. Notably, the situ activation of prodrugs or synthesis active drugs with aim complement existing treatments diseases such as cancer has received significant attention. Whereas focus initially been on optimizing ligands enhance activity and stability metal complexes, more recently benign effects compartmentalization catalyst into homogeneous heterogeneous scaffolds have unveiled. Such tailor-made carrier materials not only afford catalysts but also permit guide site interest vivo applications. This review will emphasize potential synthetic amphiphilic polymers that form compartmentalized nanostructures TMCs. The use well established field nanomedicine i.e. drug delivery purposes, their application TMCs less explored. Since are readily functionalized targeting moieties, they can act versatile carriers. After short overview state-of-the-art bioorthogonal ligand-based TMCs, we summarize advances natural catalysis. We end this by highlighting recent media embedded formed polymers. combination polymer science may open up new opportunities advancing exciting therapeutic